Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Combining DNA damaging therapeutics with immunotherapy: more haste, less speed

9 Nov 2017

Abstract excerpt

The idea that chemotherapy can be used in combination with immunotherapy may seem somewhat counterproductive, as it can theoretically eliminate the immune cells needed for antitumour immunity. However, much preclinical work has now demonstrated that in addition to direct cytotoxic effects on cancer cells, a proportion of DNA damaging agents may actually promote immunogenic cell death, alter the inflammatory...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer Immunotherapy and Biomarkers
Share to CAR-T cell therapy research
Share to Immunotherapy and Immune Responses

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 29123260
DOI: 10.1038/bjc.2017.376

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Combining DNA damaging therapeutics with immunotherapy: more haste, less speedPMID 29123260Read ↗

The complementarity of DDR, nucleic acids and anti-tumour immunity.Semantic proximity Read ↗

Targeting DNA Damage Response and Repair Genes to Enhance Anticancer Immunotherapy: Rationale and Clinical ImplicationSemantic proximity Read ↗

Impact of DNA damage response defects in cancer cells on response to immunotherapy and radiotherapy.Semantic proximity Read ↗

Immune checkpoint targeting in cancer therapy: toward combination strategies with curative potential.Semantic proximity Read ↗

The future of cancer treatment: combining radiotherapy with immunotherapySemantic proximity Read ↗

Interplay between the DNA Damage Response and Immunotherapy Response in CancerSemantic proximity Read ↗

DNA Repair and Signaling in Immune-Related Cancer TherapySemantic proximity Read ↗

Development of PARP and Immune-Checkpoint Inhibitor CombinationsSemantic proximity Read ↗

Anti-cancer immune responses to DNA damage response inhibitors: Molecular mechanisms and progress toward clinical translationSemantic proximity Read ↗

DNA Damage and Repair Biomarkers of Immunotherapy ResponseSemantic proximity Read ↗

The Impact of Chemotherapy, Radiation and Epigenetic Modifiers in Cancer Cell Expression of Immune Inhibitory and Stimulatory Molecules and Anti-Tumor EfficacySemantic proximity Read ↗

Tumor irradiation induced immunogenic response: the impact of DNA damage induction and misrepairSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.