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Article

DNA Damage-Induced Neurodegeneration in Accelerated Ageing and Alzheimer's Disease.

International journal of molecular sciences - 23 Jun 2021

Wang Heling, Lautrup Sofie, Caponio Domenica, Zhang Jianying, Fang Evandro F

Abstract excerpt

DNA repair ensures genomic stability to achieve healthy ageing, including cognitive maintenance. Mutations on genes encoding key DNA repair proteins can lead to diseases with accelerated ageing phenotypes. Some of these diseases are xeroderma pigmentosum group A (XPA, caused by mutation of XPA), Cockayne syndrome group A and group B (CSA, CSB, and are caused by mutations of CSA and CSB, respectively),...

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Identifiers

PMID: 34201700
DOI: 10.3390/ijms22136748
PMCID: PMC8268089

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