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Molecular subtyping and functional validation of TTK, TPX2, UBE2C, and LRP8 in sensitivity of TNBC to paclitaxel

25 Jan 2021

Abstract excerpt

Triple-negative breast cancer (TNBC) patients exhibit variable responses to chemotherapy, suggesting an underlying molecular heterogeneity. In the current study, we analyzed publicly available transcriptome data from 360 TNBC and 88 normal breast tissues, which revealed activation of nucleosome and cell cycle as the hallmarks of TNBC. Mechanistic network analysis identified activation of FOXM1 and ERBB2, and...

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Bioinformatics and Genomic Networks
Ferroptosis and cancer prognosis
FOXO transcription factor regulation

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 33665229
DOI: 10.1016/j.omtm.2021.01.013

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