Article

Eip74EF is a dominant modifier for ALS-FTD linked mutant VCP phenotypes in <i>Drosophila</i> , but not miR-34

2020-11-22

Abstract excerpt

In 2012 Liu et al . reported that miR-34 is an age-related miRNA regulating age-associated events and long-term brain integrity in Drosophila . They demonstrated that modulating miR-34 and its downstream target Eip74EF showed beneficial effects on age-related diseases using a Drosophila model of SCA3trQ78. These results imply that miR-34 could be a general genetic modifier and therapeutic candidate for age-rela...

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Literature Corpus work: 34a78e29-2af7-537b-9dc5-30e350b59599
DOI: 10.1101/2020.11.20.375360

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