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HuD (ELAVL4) gain-of-function impairs neuromuscular junctions and induces apoptosis in <i>in vitro</i> and <i>in vivo</i> models of amyotrophic lateral sclerosis

2023-08-23

Abstract excerpt

<h4>ABSTRACT</h4> Early defects at the neuromuscular junction (NMJ) are among the first hallmarks of the progressive neurodegenerative disease amyotrophic lateral sclerosis (ALS). According to the “dying back” hypothesis, disruption of the NMJ not only precedes, but is also a trigger for the subsequent degeneration of the motoneuron in both sporadic and familial ALS, including ALS caused by the severe FUS pathog...

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Literature Corpus work
82720844-3bb1-5ab4-995b-1844e711cfef
DOI
10.1101/2023.08.22.554258
Open publication

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HuD (ELAVL4) gain-of-function impairs neuromuscular junctions and induces apoptosis in <i>in vitro</i> and <i>in vivo</i> models of amyotrophic lateral sclerosisDOI 10.1101/2023.08.22.554258
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