Article

Expanded GGGGCC repeat transcription is mediated by the PAF1 complex in C9orf72-associated FTD.

2018-05-10

Abstract excerpt

Expression of an expanded (G4C2)30+ repeat found in C9orf72 is the most prominent mutation in familial FTD and ALS. An unbiased RNAi-based, large-scale screen in (G4C2)49-expressing Drosophila identified the CDC73/PAF1 complex (PAF1C) as a novel suppressor of (G4C2)49-toxicity. Downregulation of PAF1C, an activator of elongating RNAPII, caused suppression by reducing (G4C2)49-RNA levels. Remarkably, only PAF1C com...

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Literature Corpus work: 5f5d1bc3-4c35-518c-b0f7-cebad026ad3c
DOI: 10.1101/319376

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