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Autophagy and inflammasome molecular interplay and activation predict poor response to FLT3 inhibitors in patients with FLT3-ITD acute myeloid leukemia

2024-06-18

Abstract excerpt

<title>Abstract</title> <p>Beyond its clinical diversity and severity, acute myeloid leukemia (AML) is known for its complex molecular background and for rewiring biological processes to aid disease onset and maintenance. <italic>FLT3</italic> mutations are among the most recurring molecular entities that cooperatively drive AML, and their inhibition is a critical molecularly oriented therapeutic strategy. Despit...

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Literature Corpus work
34713321-0fa0-5898-b765-7d4c8f463bdb
DOI
10.21203/rs.3.rs-4505184/v1
Open publication

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