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Article

Autophagy activation mediates resistance to FLT3 inhibitors in acute myeloid leukemia with FLT3-ITD mutation.

Journal of translational medicine - 6 Jul 2022

Xu Dan, Chen Yishan, Yang Ying, Yin Zhao, Huang Changfen, Wang Qiang, Jiang Ling, Jiang Xuejie, Yin Changxin, Liu Qifa, Yu Guopan

Abstract excerpt

BACKGROUND: Autophagy plays a critical role in drug resistance in acute myeloid leukemia (AML), including the subtype with FLT3-ITD mutation. Yet how autophagy is activated and mediates resistance to FLT3 inhibitors in FLT3-ITD-positive AML remains unsure. METHODS: We detected the expression of autophagy markers in FLT3-ITD-positive leukemic cells after vs. before acquired resistance to FLT3 inhibitors; tested...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 35794565
DOI: 10.1186/s12967-022-03498-1
PMCID: PMC9258138

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