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Article

CRISPR screen identifies the NCOR/HDAC3 complex as a major suppressor of differentiation in rhabdomyosarcoma.

Proceedings of the National Academy of Sciences of the United States of America - 27 Dec 2016

Phelps Michael P, Bailey Jenna N, Vleeshouwer-Neumann Terra, Chen Eleanor Y

Abstract excerpt

Dysregulated gene expression resulting from abnormal epigenetic alterations including histone acetylation and deacetylation has been demonstrated to play an important role in driving tumor growth and progression. However, the mechanisms by which specific histone deacetylases (HDACs) regulate differentiation in solid tumors remains unclear. Using pediatric rhabdomyosarcoma (RMS) as a paradigm to elucidate the...

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Identifiers

PMID: 27956629
DOI: 10.1073/pnas.1610270114
PMCID: PMC5206534

Genes

HDAC3
MYOD1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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