Article

SIX1 Reprograms Myogenic Transcription Factors to Maintain the Rhabdomyosarcoma undifferentiated state

2021-04-26

Abstract excerpt

<h4>Summary</h4> Rhabdomyosarcoma (RMS) is a pediatric skeletal muscle sarcoma characterized by the expression of the myogenic-lineage transcription factors (TF) MYOD1 and MYOG. Despite high expression of these TFs, RMS cells fail to terminally differentiate, suggesting the presence of factors that alter their function. Here, we demonstrate that the developmental TF, SIX1, is highly expressed in RMS and is critic...

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Literature Corpus work: e73799a8-64c6-5a19-b506-25d9dfbd9f4a
DOI: 10.1101/2021.04.25.439216

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