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Article

PAX7 is a required target for microRNA-206-induced differentiation of fusion-negative rhabdomyosarcoma

9 Jun 2016

Abstract excerpt

Rhabdomyosarcoma (RMS) is the most common soft tissue sarcoma of childhood. RMS can be parsed based on clinical outcome into two subtypes, fusion-positive RMS (FP-RMS) or fusion-negative RMS (FN-RMS) based on the presence or absence of either PAX3-FOXO1 or PAX7-FOXO1 gene fusions. In both RMS subtypes, tumor cells show histology and a gene expression pattern resembling that of developmentally arrested skeletal...

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PMID: 27277678
DOI: 10.1038/cddis.2016.159

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