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Article

Emerging therapeutic targets for the treatment of malignant rhabdoid tumors.

Expert opinion on therapeutic targets - 1 Apr 2018

Nemes Karolina, Frühwald Michael C

Abstract excerpt

INTRODUCTION: Malignant Rhabdoid Tumor (MRT) is a rare and highly aggressive malignancy primarily affecting infants and young children. The most common anatomic locations are the central nervous system (AT/RT), the kidneys (RTK) and other soft tissues (eMRT). The genetic origin of this disease is linked to mutations in SMARCB1, a gene encoding a core subunit of the SWI/SNF chromatin-remodeling complex. Areas...

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Share to Antineoplastic Agents
Share to Chromatin Assembly and Disassembly
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 29528755
DOI: 10.1080/14728222.2018.1451839

Genes

AURKA
CDK4
GLI1
SHH
SMARCB1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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