HDAC6: Tumor Progression and Beyond

Abstract excerpt

Histone Deacetylase 6 (HDAC6) is an intriguing therapeutic target in cancer research, distinguished as the only HDAC family member predominantly located in the cytoplasm. HDAC6 features two catalytic domains and a unique ubiquitin-binding domain, which sets it apart from other HDACs. Beyond its role in histone deacetylation, HDAC6 targets various nonhistone substrates, such as α-tubulin, cortactin, Heat Shock...

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