Back to search

Article

RAC1 Regulates Shh-Medulloblastoma Growth via GLI-Mediated Transcription

2025-05-23

Abstract excerpt

Medulloblastoma (MB) is the most common malignant primary pediatric brain tumor. Current therapies are ineffective for targeting proliferation, leptomeningeal migration, and metastasis of MB cancer cells to visceral organs and therefore, novel treatments are needed. The small GTPase, RAC1, has emerged as an important regulator of actin cytoskeletal dynamics, proliferation, and migration in several cancers. However...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
fe07b15a-dc9b-5493-8836-c08d68d855f9
DOI
10.1101/2025.05.22.655563
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
RAC1 Regulates Shh-Medulloblastoma Growth via GLI-Mediated TranscriptionDOI 10.1101/2025.05.22.655563
Humanized Stem Cell Models of Pediatric Medulloblastoma Reveal an Oct4/mTOR Axis that Promotes MalignancySemantic proximity
HDAC6 promotes self-renewal and migration/invasion of rhabdomyosarcomaSemantic proximity
Signaling pathway deregulation and molecular alterations across pediatric medulloblastomas.Semantic proximity
Rho-associated kinase is a therapeutic target in neuroblastomaSemantic proximity
Medulloblastoma, WNT-activated/SHH-activated: clinical impact of molecular analysis and histogenetic evaluation.Semantic proximity
Rho GTPases signaling mediates aggressiveness and differentiation in neuroblastoma tumorsSemantic proximity
Signaling pathway and molecular subgroups of medulloblastoma.Semantic proximity
The SHH/GLI signaling pathway: a therapeutic target for medulloblastomaSemantic proximity
CK1α agonists attenuate medulloblastoma stemness and relapse riskSemantic proximity
Medulloblastoma: clinicopathological parameters, risk stratification, and survival analysis of immunohistochemically validated molecular subgroupsSemantic proximity
Targeting the Hedgehog Pathway in Pediatric MedulloblastomaSemantic proximity
Complete and sustained response of adult medulloblastoma to first-line sonic hedgehog inhibition with vismodegibSemantic proximity
Select a neighboring publication to make it the new centre.