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Article

Inhibiting glutaminase in acute myeloid leukemia: metabolic dependency of selected AML subtypes.

Oncotarget - 29 Nov 2016

Matre Polina, Velez Juliana, Jacamo Rodrigo, Qi Yuan, Su Xiaoping, Cai Tianyu, Chan Steven M, Lodi Alessia, Sweeney Shannon R, Ma Helen, Davis Richard Eric, Baran Natalia, Haferlach Torsten, Su Xiaohua, Flores Elsa Renee, Gonzalez Doriann, Konoplev Sergej, Samudio Ismael, DiNardo Courtney, Majeti Ravi, Schimmer Aaron D, Li Weiqun, Wang Taotao, Tiziani Stefano, Konopleva Marina

Abstract excerpt

Metabolic reprogramming has been described as a hallmark of transformed cancer cells. In this study, we examined the role of the glutamine (Gln) utilization pathway in acute myeloid leukemia (AML) cell lines and primary AML samples. Our results indicate that a subset of AML cell lines is sensitive to Gln deprivation. Glutaminase (GLS) is a mitochondrial enzyme that catalyzes the conversion of Gln to glutamate....

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Identifiers

PMID: 27806325
DOI: 10.18632/oncotarget.12944
PMCID: PMC5340236

Genes

GLS
IDH1
IDH2

Provenance

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