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Genomics and structural insight into the masking of gentamicin-resistance in clinical Burkholderia pseudomallei strain VB29710 from India.

Diagnostic microbiology and infectious disease - 1 Mar 2023

Bakthavatchalam Yamuna Devi, Basu Soumya, Shankar Abirami, Ramaiah Sudha, Anbarasu Anand, Veeraraghavan Balaji

Abstract excerpt

The present study reported a rare gentamicin-susceptible β-lactamase (PenA, OXA-57) expressing clinical Burkholderia pseudomallei isolate VB29710 from India. Whole-genome sequencing and structural analyses revealed the insertion of R962 and L963 into AmrB, the transmembrane-protein of the AmrAB-OprA efflux-pump that affected aminoglycoside-efflux through local alterations in backbone conformation.

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PMID: 36529021
DOI: 10.1016/j.diagmicrobio.2022.115878

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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