Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Cardiomyocyte SORBS2 expression increases in heart failure and regulates integrin interactions and extracellular matrix composition.

Cardiovascular research - 6 May 2025

Timmer Louk T, den Hertog Elvira, Versteeg Danielle, Post Harm, Verdonschot Job A J, Monshouwer-Kloots Jantine, Kyriakopoulou Eirini, Perini Ilaria, Koopmans Tim, van der Kraak Petra, Zentilin Lorena, Heymans Stephane R B, Vink Aryan, Giacca Mauro, Heck Albert J R, van Rooij Eva

Abstract excerpt

AIMS: In this study, we aimed to uncover genes associated with stressed cardiomyocytes by combining single-cell transcriptomic data sets from failing cardiac tissue from both humans and mice. METHODS AND RESULTS: Our bioinformatic analysis identified SORBS2 as conserved NPPA-correlated gene. Using mouse models and cardiac tissue from human heart failure patients, we demonstrated that SORBS2 expression is...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Extracellular Matrix
Share to Fibrosis

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to GATA4 Transcription Factor

Share to Heart Failure

Share to Integrins

Share to Myocytes, Cardiac

Share to Up-Regulation

Share to Ventricular Remodeling

Source

Open in PubMed Open full text

Identifiers

PMID: 39957251
DOI: 10.1093/cvr/cvaf021
PMCID: PMC12054630

Genes

SORBS2
GATA4
NPPA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Cardiomyocyte SORBS2 expression increases in heart failure and regulates integrin interactions and extracellular matrix composition.PMID 39957251Read ↗

Knockout of Sorbs2 in Cardiomyocytes Leads to Dilated Cardiomyopathy in MiceSemantic proximity Read ↗

RBPMS2 is a conserved regulator of alternative splicing that promotes myofibrillar organization and optimal calcium handling in cardiomyocytesSemantic proximity Read ↗

RBPMS2 Is a Myocardial-Enriched Splicing Regulator Required for Cardiac FunctionSemantic proximity Read ↗

Knockout of SORBS2 Protein Disrupts the Structural Integrity of Intercalated Disc and Manifests Features of Arrhythmogenic Cardiomyopathy.Semantic proximity Read ↗

Transcriptomic Coupling of PKP2 With Inflammatory and Immune Pathways Endogenous to Adult Cardiac MyocytesSemantic proximity Read ↗

Genomic and RNA-Seq profiling of patients with HFrEF unraveled OAS1 mutation and aggressive expression.Semantic proximity Read ↗

Interleukin-1β Drives Disease Progression in Arrhythmogenic CardiomyopathySemantic proximity Read ↗

Genome-wide association and multi-omic analyses reveal ACTN2 as a gene linked to heart failure.Semantic proximity Read ↗

Sarcomeric Remodelling in Human Heart Failure unraveled by single molecule long read sequencingSemantic proximity Read ↗

Individualized interactomes for network-based precision medicine in hypertrophic cardiomyopathy with implications for other clinical pathophenotypes.Semantic proximity Read ↗

<i>SORBS2</i> is a susceptibility gene to arrhythmogenic right ventricular cardiomyopathySemantic proximity Read ↗

Defective Desmosomal Adhesion Causes Arrhythmogenic Cardiomyopathy by Involving an Integrin-αVβ6/TGF-β Signaling CascadeSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.