Article

Abnormal patterns of sleep and waking behaviors are accompanied by increased slow gamma power in an Ank3 mouse model of epilepsy-bipolar disorder comorbidity

2022-05-09

Abstract excerpt

ANK3 is a leading bipolar disorder candidate gene in humans. Previous studies showed that deletion of Ank3-1b, a bipolar disorder (BD)-associated variant of Ank3 in mice leads to increased firing threshold and diminished action potential dynamic range of parvalbumin (PV)-interneurons and absence epilepsy, thus providing a biological mechanism linking epilepsy and BD. To better understand the impact of defective PV...

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Literature Corpus work: 341a0ea8-dfc6-5c88-889c-8bb979057925
DOI: 10.21203/rs.3.rs-1617910/v1

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