Insights into the Classical Genetics of Clitopilus passeckerianus – the Pleuromutilin Producing Mushroom

Abstract excerpt

Clitopilus passeckerianus is the fungal species responsible for the production of pleuromutilin, a diterpene antibiotic that is gaining in commercial interest. Production of the antibiotic is constrained by the low titers typically obtained from isolates. We therefore set out to investigate the possibility of using classical breeding techniques coupled with genetic manipulation as a means to develop such fungi....

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