Article

A Novel FNDC1-NAMPT-NAD axis is Implicated in Small and Large-vessel Arterial Disease and Drives Vascular Calcification

2025-07-10

Abstract excerpt

Vascular calcification represents a convergent pathological feature of diverse cardiovascular diseases, yet the upstream molecular programs orchestrating this process remain poorly defined. Here, we uncover fibronectin type III domain-containing 1 (FNDC1) as a previously unrecognized regulator of vascular calcification across both microvascular and macrovascular beds. Integrative transcriptomic profiling of human...

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Literature Corpus work: 1a8b0ea5-0b60-5aa8-a9e0-1e900a51d6b8
DOI: 10.1101/2025.07.08.663801

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