Article
MPN: The Molecular Drivers of Disease Initiation, Progression and Transformation and their Effect on Treatment.
Cells - 14 Aug 2020
Grabek Julian, Straube Jasmin, Bywater Megan, Lane Steven W
Abstract excerpt
Myeloproliferative neoplasms (MPNs) constitute a group of disorders identified by an overproduction of cells derived from myeloid lineage. The majority of MPNs have an identifiable driver mutation responsible for cytokine-independent proliferative signalling. The acquisition of coexisting mutations in chromatin modifiers, spliceosome complex components, DNA methylation modifiers, tumour suppressors and...
Topics
- Animals
- Bone Marrow Transplantation
- Disease Progression
- Humans
- Immune Checkpoint Inhibitors
- Mice
- Mutation
- Myeloproliferative Disorders
- Phenotype
- Prognosis
- Transplantation, Homologous