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Article

MPN: The Molecular Drivers of Disease Initiation, Progression and Transformation and their Effect on Treatment.

Cells - 14 Aug 2020

Grabek Julian, Straube Jasmin, Bywater Megan, Lane Steven W

Abstract excerpt

Myeloproliferative neoplasms (MPNs) constitute a group of disorders identified by an overproduction of cells derived from myeloid lineage. The majority of MPNs have an identifiable driver mutation responsible for cytokine-independent proliferative signalling. The acquisition of coexisting mutations in chromatin modifiers, spliceosome complex components, DNA methylation modifiers, tumour suppressors and...

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Identifiers

PMID: 32823933
DOI: 10.3390/cells9081901
PMCID: PMC7465511

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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