Article
Accelerated Phase of Myeloproliferative Neoplasms.
Acta haematologica - 1 Jan 2000
Shahin Omar A, Chifotides Helen T, Bose Prithviraj, Masarova Lucia, Verstovsek Srdan
Abstract excerpt
BACKGROUND: Myeloproliferative neoplasms (MPNs) can transform into blast phase MPN (leukemic transformation; MPN-BP), typically via accelerated phase MPN (MPN-AP), in ∼20-25% of the cases. MPN-AP and MPN-BP are characterized by 10-19% and ≥20% blasts, respectively. MPN-AP/BP portend a dismal prognosis with no established conventional treatment. Allogeneic hematopoietic stem cell transplantation (allo-HSCT) is the...
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