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Immunogenomic determinants of exceptional response to immune checkpoint inhibition in renal cell carcinoma

2023-07-06

Abstract excerpt

<title>Abstract</title> <p>Although immune checkpoint inhibitors can lead to “exceptional”, durable clinical responses in a subset of patients, the molecular mechanisms underlying exceptional responses (ERs) are still unknown. We analyzed pre-therapy genomic and transcriptomic data in treatment-naive patients with mccRCC treated with standard-of-care immunotherapies: (1) combination of PD-1/PDL1 and CTLA-4 (IO/IO...

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Literature Corpus work
4635fbe9-cb5c-5044-9f0f-0d6fc206d694
DOI
10.21203/rs.3.rs-3088575/v1
Open publication

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Immunogenomic determinants of exceptional response to immune checkpoint inhibition in renal cell carcinomaDOI 10.21203/rs.3.rs-3088575/v1
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