Article

LaGrACE: Estimating gene program dysregulation using latent gene regulatory network for biomedical discovery

2024-05-02

Abstract excerpt

Gene expression programs that establish and maintain specific cellular states are orchestrated through a regulatory network composed of transcription factors, cofactors, and chromatin regulators. Dysregulation of this network can lead to a broad range of diseases by altering gene programs. This article presents LaGrACE, a novel method designed to estimate dysregulation of gene programs utilizing omics data with cl...

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Literature Corpus work: b14ecfe6-d0e1-5ab2-bb9f-18bcd8687696
DOI: 10.1101/2024.04.29.591756

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