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Article

A recombinant human SLPI variant suppresses the formation of neutrophil extracellular traps at low concentrations in vitro.

Protein expression and purification - 1 Aug 2025

Jesus Gonzalez-Contreras Felipe de, Gutierrez-Vidal Roxana Guadalupe, Zarate Xristo

Abstract excerpt

Neutrophil extracellular traps (NETs) are web-like structures released by neutrophils to trap and kill microbes. While NETs are crucial in host defense, excessive formation can lead to autoimmune diseases. Currently, no specific drugs target NETs directly; however, some medications can indirectly modulate their formation. The secretory leukocyte protease inhibitor (SLPI) is a small protein that inhibits the...

Read the complete abstract on PubMed

Topics

Escherichia coli
Humans
Recombinant Proteins
Secretory Leukocyte Peptidase Inhibitor
Genetic Variation
Extracellular Traps

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Amino Acid Sequence

Protein Binding

Source

Identifiers

PMID: 40280458
DOI: 10.1016/j.pep.2025.106721

Genes

SLPI

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 19 Oct 2026.

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