Article
The conserved N-terminal SANT1-binding domain (SBD) of EZH2 regulates PRC2 activity.
Genes & development - 4 May 2026
Patriotis Agata L, Barrows Douglas W, Soto-Feliciano Yadira, Khan Laiba F, Leboeuf Marylene, Marchione Dylan M, Marunde Matthew R, Keogh Michael-Christopher, Carroll Thomas S, Garcia Benjamin A, Soshnev Alexey A, Allis C David
Abstract excerpt
Polycomb group proteins maintain gene expression patterns established during early development, with Polycomb repressive complex 2 (PRC2) methyltransferase being a key regulator of cell differentiation, identity, and plasticity. Consequently, extensive somatic mutations in PRC2, including gain or loss of function (GOF or LOF), are observed in human cancers. The regulation of chromatin structure by PRC2 is...
Topics
- Enhancer of Zeste Homolog 2 Protein
- Animals
- Protein Domains
- Humans
- Histones
- Methylation
- Polycomb Repressive Complex 2
- Cell Proliferation
- Protein Binding
- Mutation