Article

The conserved N-terminal SANT1-binding domain (SBD) of EZH2 Regulates PRC2 Activity

2025-02-05

Abstract excerpt

Polycomb group proteins maintain gene expression patterns established during early development, with Polycomb Repressive Complex 2 (PRC2) methyltransferase a key regulator of cell differentiation, identity and plasticity. Consequently, extensive somatic mutations in PRC2, including gain- or loss- of function (GOF or LOF), are observed in human cancers. The regulation of chromatin structure by PRC2 is critically de...

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Literature Corpus work: 5346ef16-40be-5708-9d6e-a88868f493b7
DOI: 10.1101/2025.02.04.636462

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