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Article

The Potential Therapeutic Applications of CRISPR/Cas9 in the Treatment of Gastrointestinal Cancers.

Current molecular medicine - 1 Jan 2025

Mehrabadi Shima, Izadi Faezeh Salmani, Pasha Shiva, Pourali Roozbeh, Khazaei Majid, Hassanian Seyed Mahdi, Ferns Gordon A, Avan Amir

Abstract excerpt

Gastrointestinal (GI) cancer is one the most prevalent types of cancer. Despite current chemotherapy's success, patients with GI cancer continue to have a dismal outcome. The onset and progression of cancer are caused by alterations and the abnormal expression of several families of genes, like tumor-suppressor genes, oncogenes, and chemotherapy-resistant genes. The final purpose of tumor therapy is to inhibit...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 38243923
DOI: 10.2174/0115665240243076231116080113

Genes

ARID1A
KRAS
PTEN
TP53
CDH1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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