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Article

CRISPR prime editing for unconstrained correction of oncogenic KRAS variants.

Communications biology - 30 Jun 2023

Jang Gayoung, Kweon Jiyeon, Kim Yongsub

Abstract excerpt

KRAS is the most commonly mutated RAS family gene and is a primary cause of the occurrence of several types of cancer. However, KRAS mutations have several unique and diverse molecular identities, making it difficult to find specific treatments. Here, we developed universal pegRNAs which can correct all types of G12 and G13 oncogenic KRAS mutations with CRISPR-mediated prime editors (PEs). The universal pegRNA...

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Identifiers

PMID: 37391511
DOI: 10.1038/s42003-023-05052-1
PMCID: PMC10313713

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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