Article

SNPD-siKRAS: siRNA specifically inhibits KRAS with a single-nucleotide mutation

2025-09-20

Abstract excerpt

<h4>SUMMARY</h4> Kirsten Rat Sarcoma Viral Oncogene Homolog ( KRAS ) is the most frequently mutated gene associated with pancreatic cancer. However, targeting mutated KRAS without affecting the wild-type KRAS expression by conventional chemotherapy is challenging, because KRAS protein is considered to be undruggable due to the lack of surface structures for drug binding. Here, we developed a single-nucleotide...

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Literature Corpus work: c8c853b5-1c17-57be-bf50-37787859c267
DOI: 10.1101/2025.09.18.677211

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