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Article

Stage-specific apoptosis, developmental delay, and embryonic lethality in mice homozygous for a targeted disruption in the murine Bloom's syndrome gene.

Genes & development - 1 Nov 1998

Chester N, Kuo F, Kozak C, O'Hara C D, Leder P

Abstract excerpt

Bloom's syndrome is a human autosomal genetic disorder characterized at the cellular level by genome instability and increased sister chomatid exchanges (SCEs). Clinical features of the disease include proportional dwarfism and a predisposition to develop a wide variety of malignancies. The human BLM gene has been cloned recently and encodes a DNA helicase. Mouse embryos homozygous for a targeted mutation in the...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 9808625
DOI: 10.1101/gad.12.21.3382
PMCID: PMC317228

Genes

BLM

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Stage-specific apoptosis, developmental delay, and embryonic lethality in mice homozygous for a targeted disruption in the murine Bloom's syndrome gene.PMID 9808625Read ↗

Mutation of the murine Bloom's syndrome gene produces global genome destabilization.Semantic proximity Read ↗

Bloom syndrome cells undergo p53-dependent apoptosis and delayed assembly of BRCA1 and NBS1 repair complexes at stalled replication forks.Semantic proximity Read ↗

Bloom helicase is involved in DNA surveillance in early S phase in vertebrate cells.Semantic proximity Read ↗

The Bloom's syndrome helicase is critical for development and function of the alphabeta T-cell lineage.Semantic proximity Read ↗

Bloom syndrome and the underlying causes of genetic instability.Semantic proximity Read ↗

Bloom syndrome helicase contributes to germ line development and longevity in zebrafishSemantic proximity Read ↗

Chromosome instability and tumor predisposition inversely correlate with BLM protein levels.Semantic proximity Read ↗

Correction of the Bloom syndrome cellular phenotypes.Semantic proximity Read ↗

Depletion of the bloom syndrome helicase stimulates homology-dependent repair at double-strand breaks in human chromosomes.Semantic proximity Read ↗

Spontaneous and induced chromosomal damage and mutations in Bloom Syndrome mice.Semantic proximity Read ↗

Genomic instability and cancer: lessons from analysis of Bloom's syndrome.Semantic proximity Read ↗

Blm Helicase Facilitates Rapid Replication of Repetitive DNA Sequences in early <i>Drosophila</i> DevelopmentSemantic proximity Read ↗

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