Article
Stage-specific apoptosis, developmental delay, and embryonic lethality in mice homozygous for a targeted disruption in the murine Bloom's syndrome gene.
Genes & development - 1 Nov 1998
Chester N, Kuo F, Kozak C, O'Hara C D, Leder P
Abstract excerpt
Bloom's syndrome is a human autosomal genetic disorder characterized at the cellular level by genome instability and increased sister chomatid exchanges (SCEs). Clinical features of the disease include proportional dwarfism and a predisposition to develop a wide variety of malignancies. The human...
Topics
- Animals
- Apoptosis
- Bloom Syndrome
- Chromosome Mapping
- Crosses, Genetic
- Embryonic Development
- Erythrocytes, Abnormal
- Female
- Gene Expression Regulation, Developmental
- Gene Targeting
- Genes, Lethal
- Homozygote
- Humans
- Mice
- Mice, Inbred C57BL
- Mice, Knockout
- Micronuclei, Chromosome-Defective
- Mutation