Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Loss of the bloom syndrome helicase increases DNA ligase 4-independent genome rearrangements and tumorigenesis in aging Drosophila.

Genome biology - 19 Dec 2011

Garcia Ana Maria, Salomon Robert N, Witsell Alice, Liepkalns Justine, Calder R Brent, Lee Moonsook, Lundell Martha, Vijg Jan, McVey Mitch

Abstract excerpt

BACKGROUND: The BLM DNA helicase plays a vital role in maintaining genome stability. Mutations in BLM cause Bloom syndrome, a rare disorder associated with cancer predisposition and premature aging. Humans and mice with blm mutations have increased frequencies of spontaneous mutagenesis, but the molecular basis of this increase is not well understood. In addition, the effect of aging on spontaneous mutagenesis in...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cell Transformation, Neoplastic
Share to DNA Breaks, Double-Stranded

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to DNA Helicases

Share to DNA Ligase ATP

Share to DNA Ligases

Share to Genes, Reporter

Share to Genomic Instability

Share to Lac Operon

Source

Open in PubMed Open full text

Identifiers

PMID: 22183041
DOI: 10.1186/gb-2011-12-12-r121
PMCID: PMC3334616

Genes

BLM

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Loss of the bloom syndrome helicase increases DNA ligase 4-independent genome rearrangements and tumorigenesis in aging Drosophila.PMID 22183041Read ↗

Drosophila BLM in double-strand break repair by synthesis-dependent strand annealing.Semantic proximity Read ↗

Formation of deletions during double-strand break repair in Drosophila DmBlm mutants occurs after strand invasion.Semantic proximity Read ↗

Enhancement of microhomology-mediated genomic rearrangements by transient loss of mouse Bloom syndrome helicase.Semantic proximity Read ↗

Mutation of the murine Bloom's syndrome gene produces global genome destabilization.Semantic proximity Read ↗

Multiple functions of Drosophila BLM helicase in maintenance of genome stability.Semantic proximity Read ↗

Bloom syndrome ortholog HIM-6 maintains genomic stability in C. elegans.Semantic proximity Read ↗

Bloom syndrome and the underlying causes of genetic instability.Semantic proximity Read ↗

Enhanced tumor formation in mice heterozygous for Blm mutation.Semantic proximity Read ↗

Depletion of the bloom syndrome helicase stimulates homology-dependent repair at double-strand breaks in human chromosomes.Semantic proximity Read ↗

Multiple functions of the ALT favorite helicase, BLMSemantic proximity Read ↗

Functions of the Bloom Syndrome Helicase N-terminal Intrinsically Disordered RegionSemantic proximity Read ↗

Blm Helicase Facilitates Rapid Replication of Repetitive DNA Sequences in early <i>Drosophila</i> DevelopmentSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.