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Predicting agranulocytosis in patients treated with clozapine – development and validation of a machine learning algorithm based on 5,550 patients

2025-03-10

Abstract excerpt

<h4>Background</h4> To prevent clozapine-induced agranulocytosis (CIA), patients’ white blood cell counts are closely monitored, with treatment stopped if the absolute neutrophil count (ANC) drops below 1.5×10 9 /L. While effective, this approach has a high rate of false positives. This study aimed to develop a machine learning (ML) decision-making tool to better predict CIA risk using pattern-based criteria (two...

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Literature Corpus work
3374255f-a219-5dbe-b53e-9f8e145a34ba
DOI
10.1101/2025.03.07.25323575
Open publication

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Predicting agranulocytosis in patients treated with clozapine – development and validation of a machine learning algorithm based on 5,550 patientsDOI 10.1101/2025.03.07.25323575
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