ACKR1/Duffy-null genotype testing for clozapine: A guideline developed by the UK Centre of Excellence in Regulatory Science and Innovation in Pharmacogenomics (CERSI-PGx).

doi:10.1002/bcp.70576

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ACKR1/Duffy-null genotype testing for clozapine: A guideline developed by the UK Centre of Excellence in Regulatory Science and Innovation in Pharmacogenomics (CERSI-PGx).

British journal of clinical pharmacology - 1 Jul 2026

Murtough Stephen, Stellakis Oriella, Mills Daisy, Bjourson Blanca, Chaplin Vicky, Chauhan Dharmisha, Chipp Bev, Cotic Marius, de Villiers Jana, Dzahini Olubanké, Elmslie Frances, Evans Katie, Gandhi Shreyans, Hughes Dyfrig A, Jin Huajie, Panconesi Daniele, Skowronska Anna, Sisodiya Sanjay M, Silva Ed, Stinton Vicky, Stuart-Smith Sara, Tarrant Sarah, Taylor David, Varney Lauren, Walters James T R, Wood Michelle, Woodley Jessica, Dello Russo Cinzia, Pirmohamed Munir, Bramon Elvira

Abstract excerpt

Clozapine is licenced for treatment-resistant schizophrenia and psychosis in Parkinson's disease. In the United Kingdom, there is a mandatory requirement for absolute neutrophil count (ANC) and white blood cell count (WBC) monitoring to safeguard against agranulocytosis. Some people have naturally low ANCs without increased infection risk, caused by a homozygous T > C variant in ACKR1, commonly called the...

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PMID: 42125771
DOI: 10.1002/bcp.70576
PMCID: PMC13304278

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ACKR1

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