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Article

Pharmacogenomics of Clozapine-induced agranulocytosis: a systematic review and meta-analysis.

The pharmacogenomics journal - 1 Jul 2022

Islam Farhana, Hain Daniel, Lewis David, Law Rebecca, Brown Lisa C, Tanner Julie-Anne, Müller Daniel J

Abstract excerpt

Although clozapine is the most effective pharmacotherapy for treatment-resistant schizophrenia, it is under-utilized, and initiation is often delayed. One reason is the occurrence of a potentially fatal adverse reaction, clozapine-induced agranulocytosis (CIA). Identifying genetic variations contributing to CIA would help predict patient risk of developing CIA and personalize treatment. Here, we (1) review...

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Identifiers

PMID: 35710824
DOI: 10.1038/s41397-022-00281-9
PMCID: PMC9363274

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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