Article

Mediation and Longitudinal Analysis to interpret the association between clozapine pharmacokinetics, pharmacogenomics, and absolute neutrophil count

2023-08-24

Abstract excerpt

Clozapine is effective at reducing symptoms of treatment-resistant schizophrenia, but it can also induce several adverse outcomes including neutropenia and agranulocytosis. We used linear mixed-effect models and structural equation modelling to determine whether pharmacokinetic and genetic variables influence absolute neutrophil count in a longitudinal UK-based sample of clozapine users not currently experiencing...

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Literature Corpus work: 6cd50cf9-0e9b-59ea-a910-dee13e0f637e
DOI: 10.1101/2023.08.22.23294262

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