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Article

Establishing the characteristics of an effective pharmacogenetic test for clozapine-induced agranulocytosis.

The pharmacogenomics journal - 1 Oct 2015

Verbelen M, Collier D A, Cohen D, MacCabe J H, Lewis C M

Abstract excerpt

Clozapine is the only evidence-based therapy for treatment-resistant schizophrenia, but it induces agranulocytosis, a rare but potentially fatal haematological adverse reaction, in less than 1% of users. To improve safety, the drug is subject to mandatory haematological monitoring throughout the course of treatment, which is burdensome for the patient and one of the main reasons clozapine is underused. Therefore,...

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Identifiers

PMID: 25732907
DOI: 10.1038/tpj.2015.5
PMCID: PMC4762904

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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