Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Establishing the characteristics of an effective pharmacogenetic test for clozapine-induced agranulocytosis.

The pharmacogenomics journal - 1 Oct 2015

Verbelen M, Collier D A, Cohen D, MacCabe J H, Lewis C M

Abstract excerpt

Clozapine is the only evidence-based therapy for treatment-resistant schizophrenia, but it induces agranulocytosis, a rare but potentially fatal haematological adverse reaction, in less than 1% of users. To improve safety, the drug is subject to mandatory haematological monitoring throughout the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Clozapine
Share to Drug Hypersensitivity
Share to HLA-DQ beta-Chains

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Pharmacogenetics

Share to Polymorphism, Single Nucleotide

Share to Risk Factors

Share to Schizophrenia

Source

Open in PubMed Open full text

Identifiers

PMID: 25732907
DOI: 10.1038/tpj.2015.5
PMCID: PMC4762904

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-25732907-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Establishing the characteristics of an effective pharmacogenetic test for clozapine-induced agranulocytosis.PMID 25732907Read ↗

Clozapine Pharmacogenetic Studies in Schizophrenia: Efficacy and AgranulocytosisSemantic proximity Read ↗

Clozapine-induced agranulocytosis and its genetic determinants.Semantic proximity Read ↗

Pharmacogenetics of Antipsychotic Drug Treatment: Update and Clinical ImplicationsSemantic proximity Read ↗

Pharmacogenomics of Clozapine-induced agranulocytosis: a systematic review and meta-analysis.Semantic proximity Read ↗

Pharmacogenetics of antipsychotics: recent progress and methodological issuesSemantic proximity Read ↗

Clozapine-induced agranulocytosis is associated with rare HLA-DQB1 and HLA-B alleles.Semantic proximity Read ↗

Cost-effectiveness of HLA-DQB1/HLA-B pharmacogenetic-guided treatment and blood monitoring in US patients taking clozapine.Semantic proximity Read ↗

Predicting agranulocytosis in patients treated with clozapine – development and validation of a machine learning algorithm based on 5,550 patientsSemantic proximity Read ↗

Further evidence of human leukocyte antigen-encoded susceptibility to clozapine-induced agranulocytosis independent of ancestry.Semantic proximity Read ↗

Clozapine rechallenge after excluding the high-risk clozapine-induced agranulocytosis genotype of HLA-DQB1 6672G>C.Semantic proximity Read ↗

Genetic risk factors for clozapine-induced neutropenia and agranulocytosis in a Dutch psychiatric population.Semantic proximity Read ↗

Candidate gene analysis identifies a polymorphism in HLA-DQB1 associated with clozapine-induced agranulocytosis.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.