Article

IKAROS facilitates antigen escape in the face of CD19- and CD22-targeted therapies for B-cell acute lymphoblastic leukemia

2024-11-03

Abstract excerpt

<h4>Summary</h4> Relapse due to antigen escape is a major cause of treatment failure for patients with B-cell malignancies following targeted immunotherapies, including CD19- and CD22-directed chimeric antigen receptor T (CAR T) cells. To identify tumor intrinsic factors associated with antigen loss, we performed single-cell analyses on 61 primary patient samples or patient-derived xenografts from patients with B...

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Literature Corpus work: d9a6f14c-055d-5e46-9e34-c6fb7aa5dacf
DOI: 10.1101/2024.11.01.621347

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