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Effect of Pressure on the Conformational Landscape of Human <i>γ</i> D-crystallin from Replica Exchange Molecular Dynamics Simulations

2024-01-07

Abstract excerpt

Human γ D-crystallin belongs to a crucial family of proteins known as crystallins located in fiber cells of the human lens. Since crystallins do not undergo any turnover after birth, they need to possess remarkable thermodynamic stability. However, their sporadic misfolding and aggregation, triggered by environmental perturbations or genetic mutations, constitute the molecular basis of cataracts, which is the pri...

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Literature Corpus work
335fc811-0bb1-5387-9518-43a845110924
DOI
10.1101/2024.01.07.574493
Open publication

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