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Article

Determinants of neuroglobin plasticity highlighted by joint coarse-grained simulations and high pressure crystallography.

Scientific reports - 12 May 2017

Colloc'h Nathalie, Sacquin-Mora Sophie, Avella Giovanna, Dhaussy Anne-Claire, Prangé Thierry, Vallone Beatrice, Girard Eric

Abstract excerpt

Investigating the effect of pressure sheds light on the dynamics and plasticity of proteins, intrinsically correlated to functional efficiency. Here we detail the structural response to pressure of neuroglobin (Ngb), a hexacoordinate globin likely to be involved in neuroprotection. In murine Ngb, reversible coordination is achieved by repositioning the heme more deeply into a large internal cavity, the "heme...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 28500341
DOI: 10.1038/s41598-017-02097-1
PMCID: PMC5431840

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