Influence of Cataract Causing Mutations on αA-Crystallin: A Computational Approach.

Abstract excerpt

The αA-crystallin protein plays a vital role in maintaining the refractive index and transparency of the eye lens. Significant clinical studies have emerged as the αA-crystallin is prone to aggregation, resulting in the formation of cataracts with varied etiologies due to mutations. This work aims to comprehend the structural and functional role of cataract-causing mutations in αA-crystallin, particularly at...

Topics

Join the communities discussing this publication.

• Cataract
• Crystallins
• Molecular Dynamics Simulation
• Mutation
• Protein Domains