Article

Conformational catalysis of cataract-associated aggregation in a human eye lens crystallin occurs via interface stealing

2019-04-07

Abstract excerpt

Human γD-crystallin (HγD) is an abundant and highly stable two-domain protein in the core region of the eye lens. Destabilizing mutations and post-translational modifications in this protein are linked to onset of aggregation that causes cataract disease (lens turbidity). Wild-type HγD greatly accelerates aggregation of the cataract-related W42Q variant, without itself aggregating. The mechanism of this “inverse p...

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Literature Corpus work: 3393f5e3-d35a-5c55-bff3-63dec01d3af8
DOI: 10.1101/601708

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