Article

Double Domain Swapping in Human <i>γ</i> C and <i>γ</i> D Crystallin Drives Early Stages of Aggregation

2020-07-19

Abstract excerpt

Human γ D (H γ D) and γ C (H γ C) are double domained crystallin (Crys) proteins expressed in the nucleus of the eye lens. Structural perturbations in the protein often trigger aggregation, which eventually leads to cataract. To decipher the underlying molecular mechanism, it is important to characterize the partially unfolded conformations of Crys proteins. Using coarse grained protein models and molecular dy...

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Literature Corpus work: 064e4998-df5d-562b-b076-d05e78e268ea
DOI: 10.1101/2020.07.18.210443

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