Article

Atomistic Modeling of Liquid-Liquid Phase Equilibrium Explains Dependence of Critical Temperature on γ-Crystallin Sequence

2023-04-28

Abstract excerpt

Liquid-liquid phase separation of protein solutions has regained heightened attention for its biological importance and pathogenic relevance. Coarse-grained models are limited when explaining residue-level effects on phase equilibrium. Here we report phase diagrams for γ-crystallins using atomistic modeling. The calculations were made possible by combining our FMAP method for computing chemical potentials and Brow...

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Identifiers and source

Literature Corpus work: 9874972a-858b-5948-afa8-c1c0191d04d2
DOI: 10.1101/2023.04.25.538329

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