Article
Discovery of structural alterations in solid tumor oligodendroglioma by single molecule analysis.
BMC genomics - 26 Jul 2013
Ray Mohana, Goldstein Steve, Zhou Shiguo, Potamousis Konstantinos, Sarkar Deepayan, Newton Michael A, Esterberg Elizabeth, Kendziorski Christina, Bogler Oliver, Schwartz David C
Abstract excerpt
BACKGROUND: Solid tumors present a panoply of genomic alterations, from single base changes to the gain or loss of entire chromosomes. Although aberrations at the two extremes of this spectrum are readily defined, comprehensive discernment of the complex and disperse mutational spectrum of cancer genomes remains a significant challenge for current genome analysis platforms. In this context, high throughput,...
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