Article

A multi-platform reference for somatic structural variation detection

2020-10-16

Abstract excerpt

Accurate detection of somatic structural variation (SV) in cancer genomes remains a challenging problem. This is in part due to the lack of high-quality gold standard datasets that enable the benchmarking of experimental approaches and bioinformatic analysis pipelines for comprehensive somatic SV detection. Here, we approached this challenge by genome-wide somatic SV analysis of the paired melanoma and normal lymp...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 266be27d-3141-5c9e-b35b-914966f29af6
DOI: 10.1101/2020.10.15.340497

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

A multi-platform reference for somatic structural variation detectionDOI 10.1101/2020.10.15.340497Read

A somatic reference standard for cancer genome sequencing.Semantic proximity Read

Donor-specific assemblies enhance somatic structural variant detection in complex genomic regionsSemantic proximity Read

Deep sequencing of 3 cancer cell lines on 2 sequencing platformsSemantic proximity Read

Deep whole-genome sequencing of 3 cancer cell lines on 2 sequencing platforms.Semantic proximity Read

The benefit of a complete reference genome for cancer structural variant analysisSemantic proximity Read

Diploid donor-specific assembly enhances somatic structural variant detection in cancer genomesSemantic proximity Read

Comprehensive benchmarking of somatic structural variant detection at ultra-low allele fractionsSemantic proximity Read

Rapid identification of genomic structural variations with nanopore sequencing enables blood-based cancer monitoringSemantic proximity Read

Detection of somatic structural variants from short-read next-generation sequencing dataSemantic proximity Read

Accurate identification of structural variations from cancer samplesSemantic proximity Read

DeepSomatic: Accurate somatic small variant discovery for multiple sequencing technologiesSemantic proximity Read

Cost-effective hybrid long- and short-read sequencing enables accurate somatic structural variant detectionSemantic proximity Read