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Genetic engineering of porcine endothelial cell lines for evaluation of human-to-pig xenoreactive immune responses

23 Jun 2021

Abstract excerpt

Xenotransplantation (cross-species transplantation) using genetically-engineered pig organs offers a potential solution to address persistent organ shortage. Current evaluation of porcine genetic modifications is to monitor the nonhuman primate immune response and survival after pig organ xenotransplantation. This measure is an essential step before clinical xenotransplantation trials, but it is time-consuming,...

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PMID: 34162938
DOI: 10.1038/s41598-021-92543-y

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