Article
Exome sequencing identifies somatic gain-of-function PPM1D mutations in brainstem gliomas.
Nature genetics - 1 Jul 2014
Zhang Liwei, Chen Lee H, Wan Hong, Yang Rui, Wang Zhaohui, Feng Jie, Yang Shaohua, Jones Siân, Wang Sizhen, Zhou Weixin, Zhu Huishan, Killela Patrick J, Zhang Junting, Wu Zhen, Li Guilin, Hao Shuyu, Wang Yu, Webb Joseph B, Friedman Henry S, Friedman Allan H, McLendon Roger E, He Yiping, Reitman Zachary J, Bigner Darell D, Yan Hai
Abstract excerpt
Gliomas arising in the brainstem and thalamus are devastating tumors that are difficult to surgically resect. To determine the genetic and epigenetic landscape of these tumors, we performed exomic sequencing of 14 brainstem gliomas (BSGs) and 12 thalamic gliomas. We also performed targeted mutati...
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