Article

cMYC-mediated immune repression is reversed by inhibition of H3K9/H3K27 methylation maintenance

2023-10-20

Abstract excerpt

Aberrant cMYC activity is a key driver of cancer, involved in several hallmark processes. Alongside the canonical hallmark of proliferation, cMYC represses immune signalling in a cell-intrinsic manner. The histone methyltransferases EZH2 and G9a interact with cMYC to modulate gene expression, including repression of immune genes via H3K27 and H3K9 histone methylation. Analyses of 565 cell lines derived from solid...

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Literature Corpus work: 332f7f34-ebd2-5f3b-bb82-7c1ad7b17736
DOI: 10.1101/2023.10.18.562888

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