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Article

MCM10 compensates for Myc‐induced DNA replication stress in breast cancer stem‐like cells

19 Dec 2020

Abstract excerpt

Cancer stem-like cells (CSCs) induce drug resistance and recurrence of tumors when they experience DNA replication stress. However, the mechanisms underlying DNA replication stress in CSCs and its compensation remain unclear. Here, we demonstrate that upregulated c-Myc expression induces stronger DNA replication stress in patient-derived breast CSCs than in differentiated cancer cells. Our results suggest...

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PMID: 33340428
DOI: 10.1111/cas.14776

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